Metabolic determinants in Listeria monocytogenes anaerobic listeriolysin O production
نویسندگان
چکیده
منابع مشابه
Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes
Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores. Some effects of the toxins are observed in non-lytic concentrations. Two pathogens, Streptococcus pneumoniae and Listeria monocytogenes, cause fatal bacterial meningitis, and ...
متن کاملListeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule.
Infection of mice with Listeria monocytogenes caused marked lymphocyte apoptosis in the white pulp of the spleen on day 2 postinfection. We prove in this study that listeriolysin O (LLO), a pore-forming molecule and a major virulence factor of Listeria, could directly induce murine lymphocyte apoptosis both in vivo and in vitro at nanomolar and subnanomolar doses. Induction of apoptosis by LLO ...
متن کاملCold shock proteins contribute to the regulation of listeriolysin O production in Listeria monocytogenes.
Cold shock proteins (Csps) are multifunctional nucleic acid binding proteins used to regulate a wide range of gene expression responses in bacteria. We report here that Csps regulate the production of the pore-forming cytolysin listeriolysin (LLO) and hemolysis phenotypes in Listeria monocytogenes. A triple csp gene deletion mutant incapable of producing any Csps, as well as double csp gene del...
متن کاملProduction of listeriolysin by beta-hemolytic strains of Listeria monocytogenes.
Listeriolysin was isolated from target rabbit erythrocyte membranes after lysis of the cells with partially purified toxin derived from a culture supernatant of Listeria ivanovii. The membrane form of the toxin exhibited properties similar to those previously found for streptolysin O. Detergent-solubilized, delipidated listeriolysin was found to comprise a heterogeneous population of partially ...
متن کاملFisetin Protects Against Listeria monocytogenes Infection by Reducing the Production of Listeriolysin O.
TO THE EDITOR—We read with great interest the recent publication by Wang et al about the direct interference of the flavonoid fisetin with the activity of the poreforming toxin listeriolysin O (LLO) from Listeria monocytogenes, which results in reduced virulence of the pathogen [1]. Recently, we found that pretreatment of the murine macrophages cell line P388D1 with fisetin prior to L. monocyto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Microbiology
سال: 2017
ISSN: 0302-8933,1432-072X
DOI: 10.1007/s00203-017-1355-4